{"id":5882,"date":"2024-01-12T16:55:04","date_gmt":"2024-01-12T15:55:04","guid":{"rendered":"https:\/\/hemerapharma.com\/?p=5882"},"modified":"2025-06-19T11:58:43","modified_gmt":"2025-06-19T09:58:43","slug":"massimo-locati-in-first-person","status":"publish","type":"post","link":"https:\/\/hemerapharma.com\/en\/massimo-locati-in-first-person\/","title":{"rendered":"Massimo Locati"},"content":{"rendered":"

We\u2019re kicking off the new year with #Hemerainfirstperson<\/strong>, our interview series featuring the members of our dream team.Today, it\u2019s the turn of Prof. Massimo Locati<\/strong>, Hemera\u2019s Scientific Director.<\/p>\n

How did the team composition influence the birth and development of the proof of concept for the therapy?<\/strong><\/h2>\n

Regenerative therapy is one of the great promises of modern medicine, a frontier with immense potential; yet it is also one of the fields where painful setbacks have been recorded for years. The main reason for these failures is the difficulty of effectively acting in a scenario characterized by multiple biological processes that intertwine and influence each other. Hemera\u2019s experience shows that our chances improve when different skills synergize. In Hemera\u2019s case, the cross-fertilization between neuroscience and immunology expertise created an ideal environment to focus on an innovative regenerative medicine approach that isolated individual skills could never have grasped.<\/p>\n

What is the main scientific value of Hemera\u2019s innovation with REMaST?<\/strong><\/h2>\n

REMaST shifts the focus of regenerative approaches from the specific cell of the damaged tissue to the context as a whole, technically known as the \u2018microenvironment.\u2019 In particular, in the neuroregenerative field, experience has shown the limits of approaches aimed directly at supporting neuronal cell regeneration, for example using various types of stem cells. Specifically, in injured nervous tissue, a hostile environment forms that prevents regeneration by stem cells. Hemera\u2019s innovation consists of a therapeutic approach shift, using another cell type\u2014macrophages\u2014that can act on the hostile microenvironment.<\/p>\n

What are macrophages and why are they important?<\/strong><\/h2>\n

Macrophages are immune cells, traditionally considered involved in defense processes; however, these cells also have the function of creating, in damaged organs, the best microenvironmental conditions for the organ\u2019s inherent regenerative potential to be expressed. In many contexts, this synergy guarantees excellent regenerative capacities\u2014but not in the central nervous system. We have known for years about the pro-regenerative functions of macrophages, but until now, this potential has not been exploited to generate innovative forms of therapy.<\/p>\n

How does the tissue regeneration process induced by Hemera\u2019s therapy work?<\/strong><\/h2>\n

REMaST is a cellular preparation made up of macrophages trained in vitro to maximize their regeneration-promoting functions. Our preclinical data show that, in a specific functional state induced by our company\u2019s patented method, these cells express certain properties that collectively enable the regeneration of tissues\u2014such as the nervous system\u2014that have a low repair propensity. Studying their therapeutic capabilities, we realized that REMaST\u00ae acts on several aspects of the repair and regeneration process.<\/p>\n

They improve neuron survival by acting directly on these nerve cells, but they also affect other structures involved in the damage. In particular, they stimulate the formation of new blood vessels, improving the supply of blood and oxygen necessary to support regeneration, and they remodel the scar that develops at the injury site, which compromises nerve impulse transmission. Rather than acting like a classic drug targeting a specific biological function, REMaST\u00ae<\/strong> acts like a \u2018bioreactor,\u2019 deploying multiple functions that collectively achieve the results demonstrated by our preclinical data.<\/p>\n","protected":false},"excerpt":{"rendered":"

We\u2019re kicking off the new year with #Hemerainfirstperson, our interview series featuring the members of our dream team.Today, it\u2019s the turn of Prof. Massimo Locati, Hemera\u2019s Scientific Director. How did the team composition influence the birth and development of the proof of concept for the therapy? Regenerative therapy is one of the great promises of […]<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[39],"tags":[],"class_list":["post-5882","post","type-post","status-publish","format-standard","hentry","category-hemera-in-prima-persona"],"acf":[],"_links":{"self":[{"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/posts\/5882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/comments?post=5882"}],"version-history":[{"count":2,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/posts\/5882\/revisions"}],"predecessor-version":[{"id":5886,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/posts\/5882\/revisions\/5886"}],"wp:attachment":[{"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/media?parent=5882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/categories?post=5882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hemerapharma.com\/en\/wp-json\/wp\/v2\/tags?post=5882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}