MEETING OF THE SCIENTIFIC ADVISORY BOARD

The Scientific Advisory Boar composed of Prof. Alberto Mantovani (Scientific Director of Humanitas Clinical Institute), Prof. Giorgio Racagni (Honorary President of the Italian Society of Pharmacology), and Dr. Tiziana Redaelli (Emeritus Head of the Spinal Unit at Niguarda Metropolitan Hospital)—convened in Milan to discuss strategic aspects of the company’s scientific development.

The agenda of this first meeting included the following presentations:

• Our History | Guido Fumagalli, President and Chief Medical Officer

• Who We Are and Where We’re Going | Cristiana Vignoli, CEO

• REMaST® | Massimo Locati, Scientific Director

• Preclinical Results | Ilaria Decimo, Director of Research & Development

• Development of REMaST up to GLP | Francesco Bifari, Director of Therapy Development

• Clinical Studies | Giuseppe Dastoli, Director of Clinical Development

• Strategic Positioning | Gianfranco Bellezza, Scientific Marketing Manager

FIRST PATIENT ENROLLED IN THE OBSERVATIONAL STUDY

As part of the prospective observational study launched in several Centers of Excellence in Northern Italy, the first patient with a complete and acute spinal cord injury was enrolled on July 17 at Niguarda Metropolitan Hospital in Milan. The patient will be monitored over the next 12 months to collect neurophysiological data and parameters that will inform the design of the upcoming interventional pharmacological trial using the REMaST® cell therapy, scheduled to begin in 2025.

Niguarda Hospital in Milan is a recognized center of excellence for the treatment and rehabilitation of spinal cord injuries. Its Spinal Unit, led by Dr. Michele Spinelli, is one of the leading rehabilitation centers in Italy for individuals with traumatic spinal cord conditions requiring specialized rehabilitation programs.

The medical team includes physiatrists, urologists, neurologists, anesthesiologists, and benefits from the support of numerous other specialists.

With 30 beds and approximately 120 admissions per year, the facility is a national reference point for spinal cord injury patients from across Italy.